Levels of Blood Biomarkers among Patients with Myocardial Infarction in Comparison to Control Group

Abstract

BACKGROUND: Myocardial infarction (MI) as a term for aheart attack happens due to reduced blood flow to heartmyocardium and lack of oxygen supply caused by plaques inthe interior walls of coronary arteries. With respect to theimportance of MI etiology, we aimed to study the relationshipof MI and blood examination variables.

METHODS: This study was conducted in Mazandaran HeartCenter as a hospital-based case-control Comprising 894participants including 465 cases and 429 controls,individually matched by sex and age. Considered bloodmarkers were analyzed using routine laboratory methods andequipment.

RESULTS: Of all participants, 64.3% of the cases and 51.0%of the controls were males with a mean age of 61.2 (±13.8) incases and 62.4 (±14.) in controls. We could not find anydifferences between cases and controls for total cholesterol(TC), low-density lipoprotein (LDL), high-density lipoprotein(HDL), and alkaline-phosphatase (ALP) (P>0.05). However,levels of creatine-kinase-muscle/brain (CK-MB) (P<0.0001),fasting-blood-sugar(FBS)(P<0.0001),aspartate-aminotransferase (AST) (P<0.0001), alanine-transferase(ALT) (P<0.0001) and erythrocyte sedimentation rate (ESR)(P=0.001) were significantly higher in cases compared to thecontrols (P<0.05). Multivariable analyses revealed that therisk of MI was associated with high levels of AST (adjustedOR=24.3, 95%CI=3.5±165.6, P=0.001) and LDL (adjustedOR=7.4, 95%CI=1.0±51.8, P=0.001).

CONCLUSION: Our investigation indicated that the levels ofCK-MB, FBS, AST, ALT and ESR were significantly higherin patients with MI. Besides, our findings showed that therisk of MI in cases with high levels of AST and LDL wasabout 24 and 7 times more than the control grouprespectively.