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BACKGROUND: The biochemical reference ranges currently used in developing countries are derived from data collected from populations living in developed countries. However, it is a fact that there is considerable variation in biochemical reference intervals by several variables. Moreover, reference ranges provided by different laboratory manuals and books do not also solve this problem. Biochemical profile at population level is scanty in the Ethiopian situation. Therefore, this study was conducted to determine the biochemical profiles for general population in community settings. METHODS: A population-based cross-sectional study was conducted in Gilgel Gibe Field Research Center (GGFRC) from late September 2008 to end of January 2009. The study setting included both rural (majority) and urban dwellers. A total of 1,965 (955 men and 1010 women) individuals aged 15-64 years were included. Fasting blood glucose was determined immediately at field. Blood sample was collected by vacutainer tube without anticoagulant and transported to Jimma University Specialized Hospital laboratory for determination of total cholesterol, triglycerides, total serum protein, blood urea nitrogen, creatnine, uric acid, alanine aminotransferase and aspartate aminotransferase. Data were entered into EpiData and analyzed using SPSS for Windows version 16.0 and STATA 11. RESULTS: The mean total cholesterol value for both sexes was 141.0 mg/dl with higher values for women at different age strata. The mean FBS level of the study population was 96 mg/dl. The mean values for blood urea nitrogen, creatinine and uric acid were 14.1 mg/dl, 0.86 mg/dl and 4.4 mg/dl. The mean level of alanine aminotransferase and aspartate aminotransferase of the study population were 27.2 U/L and 31.2 U/L, respectively. CONCLUSION: All biochemical values in this study except for blood urea nitrogen were not different from values in other reports. Even though our finding showed similar ranges with reported values, there might be a variation in values across the country. Therefore, we recommend conducting similar nationally representative study to validate the current finding. .