A Status of Serum and Salivary Levels of Superoxide Dismutase in Type 2 Diabetes Mellitus with Oral Manifestations Case Control Study

Abstract

BACKGROUND: Type 2 Diabetes Mellitus is a very well known metabolic disorder that has reachedepidemic proportions worldwide. Evidence suggests that oxidative stress increases in Diabetes Mellitusbecause of the excessive production of reactive oxygen species and an impaired antioxidant defencemechanism. This study estimated, compared and correlated the serum and salivary Superoxide dismutaselevels in healthy subjects and subjects with Type 2 Diabetes Mellitus having oral manifestations.MATERIALS AND METHODS: In this study, serum and salivary Superoxide dismutase levels wereestimated in 45 healthy subjects and 45 patients with Type 2 Diabetes Mellitus with oral manifestations.RESULTS: The mean serum and salivary Superoxide dismutase levels were significantly decreased insubjects with Type 2 Diabetes Mellitus with oral manifestations compared to the healthy subjects.Positive correlation in both healthy and diabetics was observed between serum and salivary samples.CONCLUSION: This study highlights that the abnormally high levels of oxidative stress in diabeticscoupled with simultaneous decline in antioxidant defence mechanism results in complications inDiabetes mellitus. Thus exploring saliva for antioxidant markers that accurately reflect the redox statusof the body is worthwhile.t