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BACKGROUND: The quality of life (QoL) construct has alsocontributed to understanding the comprehension of factors involvedin the existence of people infected by the HIV/AIDS. The objectiveof this study is to assess the quality of life (QoL) of people withHIV/AIDS (PLWHA) in Wonogiri District, Indonesia.METHODS: A cross-sectional study was conducted from Septemberto November 2017. Convenience sampling method was employed torecruit 39 people living with HIV/AIDS (PLWHA) at VoluntaryCounselling and Testing (VCT) of Wonogiri, Indonesia. Researchdata were collected using a self-administered questionnaire ofWHOQOL-HIV BREF. The data were further analysed using a t-test and a Chi-square test, while linear regression was used toevaluate factors that correlate with the PLWHAs’ quality of life.RESULTS: The results showed that the gross mean score of socialrelationships domain is 13.59; psychological domain is 13.31;environment domain is 13.28; spiritual/personal beliefs domainis13.15; physical domain is 13.10; and level of independence domainis 13.77. The symptom of HIV is associated with quality of life (B =7.611, β = 0.362, t = 2,046, p value = 0.049).CONCLUSION: Healthcare provider should increase provider-initiated testing and counselling (PITC) to contracting group, highrisk group, susceptible group, and the community. The PLWHA arerecommended to actively participate in peer support groups (PSGs)so that they can improve their quality of life.